I haven't had any major issues with H110, but I have only loaded subsonic with it.
I've read and have been told that H110 is very temperature sensitive, so I'm using caution when the temp reaches 90 degrees or more. I like going to the Oregon/Nevada border and shooting. From Memorial Day and throughout the summer, the temp can be near freezing (or colder) at night to above 100 degrees duting the day. So I won't be using H110 after mid-morning.
My big gripe was how dirty my brass gets using H110. Ramshot Enforcer was recommended to me as being a very clean burning powder, so that's what I'm loading now.
Ramshot sent me load data for the 300 Whisper. I haven't shot any of these Ramshot Enforcer rounds yet, but I do intend to post on this forum if it has met my expectations.
VihtaVuori powder is the only powder that has been recommended as burning even cleaner than Ramshot Enforcer, but all of the VihtaVuori powders are very hard to get in my area.