Just a couple of observations...
Over the years I have taken Whitetail with a muzzleloader. 45/50/58 calibers. Slow moving round ball, little to no shock damage. All shots thru the lungs, round exit hole with little tissue disruption on the entrance or exit hole. Both lungs fill with blood, longest one ran was 75 yards. I never put these loads over the Chrony but 45 grains of FFF in the 45, 50 gr. of FFF in the 50 and 65 gr of FF in the 58 can't be going too fast. But they did the job.
I also bow hunt and there is little tissue damage done by disruption all by cutting. Again all shots thru both lungs, furthest deer ever ran was 80 yards before it piled up dead.
Todate all kills have been one shot and zero lost. It does require waiting for the proper shot and I have not taken a deer that was further away than 50 yards, some as close as 20 yards.
Also there is a local professional hunter that culls deer heards for local gov't and the DNR and it is my understanding he uses a whisper as he is in closer to populated areas. Gunshots raise the awareness of the anti gunners/hunters so I am assuming he is using a silenced weapon (aka: subsonic). I found this out when discussing the whisper at the local gunshop where I buy loading supplies, the shop owner said I was only the 2nd person he had ever heard reference the 300 whisper, the other guy buys his reloading stuff at the same shop.
Don't get me wrong, I think a prudent hunter should use a weapon of adequate ballistics to properly dispense what ever they hunt (rabbits to dinosaurs) but adequate can mean different things to different people based on the limitation of the weapon being used and the hunters skills. I would sum up hunting with a Whisper similar to hunting with a Bow as far as range and game taking ability.
Just my $0.02.........
DonT