Paul, You ask a "loaded" question
. I've been fooling around with a .338 X 39 round in a very tight twist, that is shooting Very
accurately with both 250 and 300 grain bullets'
The 510 whisper is no slouch when using Amax bullets and I've heard good things about Lehigh bullets in both 50 and 458 caliber.
This should generate a lot of argument, but I'll go out on a limb and say equipment and smithing matter a Lot more than caliber.