Here is my Opinion based on my experience with the .300 whisper and the AR Platform as well as .308 bolt gun platforms tempered with 40 years shooting & reloading experience.
I like AR's they are excellent weapons for what they were designed to do as well has having fun. Nothing draws a group at the range like me throwing 2 levers, pulling the barrel on my MGI uppered rifle and sliding in a different caliber, throw the levers, redial the scope and we are off and running in a whole different caliber. My experience in this area is based on a dedicated AR in .300 Whisper, and a MGI QCB (Quick Change Barrel) Upper with 4 barrels (.300 Whisper/.223/7.62x39/.17-223) with a DPMS lower. I also have another collapsible stocked lower with a 16" upper dedicated to 5.56 nato.
BUT................
For accuracy, reliability hunting I would choose a Savage 12Bvss in .308 and here is why:
With the Accutrigger you get an excellent trigger out of the box.
In a pinch .308 ammo is available almost anywhere.
It, for the most part, is not finicky as far as functioning with different bullets, powder, brass, seating depth, trim length, etc.
It allows you to change loads at will without a special gas system.
It will function with the same ammo in subzero weather that you use in +80 degree weather (I live in Sunny Warm Minnesota so have first hand expereince with this).
And for a meager investment in a barrel nut wrench ($25), barrel blocks ($50), a .223 bolt head w/extractor ($25) and a .300 Whisper barrel ($250 and up, check with Spook on this board he did a NICE one for me) that is threaded and chambered you can switch calibers in about 15 to 20 minutes (with a little practice).
I base the information provided on the bolt gun on the fact I have had 3 Savage 12Bvss' in the last few years. One in .308 (still have), one in .223 and one in .300 Whisper (which I regret getting talked out of). This is a very versatile platform allowing for various combinations (as long as you stay with the shorter cartridges in the .308 and shorter family). Barrel changes can be done at home or anywhere you have access to vise, can be done by anyone with a little understanding of firearms and common sense and for substantially less than you will wrap up in one AR Platform rifle dedicated to .300 whisper.
If I had it to do over again I would get myself a couple of Savage 12Bvss (this one has a nice laminated wood stock with lots of beef to it and comes pillared with free floating barrel) and the barrels in the lengths I wanted and calibers I needed and keep a whole lot of money in my pocket. AND if you were going to hunt somewhere where the suppressor might cause you greif you could have 2 barrels set up and just remove the one with the can and put the one without on the gun, then you don't have to explain why the end has that funny appliance on it or is threaded...
When running the lower end of the power curve (subsonic) with semi-autos you are suseptible to malfunctions with drastic changes in temperature. Ask the guys I shot with last weekend in our pistol leagues who where shooting semi-autos with homerolled target ammo outdoors in -10 temps. My old wheel gun didn't seem too slow to them when they started getting failure to feeds, failure to ejects and stove pipes due to the powder-temp combinations.
Anyhow this is one old guys opinion and I am sure many will find fault in the my line of thinking but when someone asks for an opinion I like it to be based on what I have hands on experience with and even then it only makes it right for me...
Good luck in your quest...
DonT