The only downsides I've seen to using cast bullets in a .300 AR, are that they are a little smokey (even gas-checked), and there gets to be a little lead buildup on the boat tail-- no big deal to scrape it off.
On the other hand, this is only maybe 300 rounds' experience. I suppose firing 10X that might show some other concerns, but I'd be surprised if it was anything that could not be dealt with.
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