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I don't think the S&W cylinder is long enough. I don't have the cylinder length, but .460 OAL is 2.3" vs. 2.5" .410 shells + the need for space for the crimp to go upon firing.
At a minimum, I'm guessing that you'd tie up your revolver if you tried it. If you want to shoot shotshells, I guess you're stuck with loading some in .45 colt cases.
For solid projectiles, I don't know what you could get out of a .410 shell that you couldn't do better with a brass case in .45 colt, .454, or .460. And as big as my .460XVR is, I don't know that I'd want to shoot shotshells of any sort in it. It's not the handiest thing around, but it is definitely fun to shoot.
Crawdaddy
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