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I haven't ever tried 4227 in .300 Whisper. However, it is my least favorite powder that I've used in magnum revolver cartridges.
It is a stick powder, so it doesn't meter all that well.
Even with full-power loads, I would always get a lot of unburned and partially burned granules thrown all over the place. I mean a lot! Shooting with these loads felt like having someone throw a handful of sand on my arms and head. The inside of the gun looked like it had been dragged across the beach too.
I'm thinking there are probably better choices.
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