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The Sierra book has data for the 300/221, but it is for a Contender pistol, so you'll need to adjust according to your barrel length. With a 240 grain bullet and an 18 inch barrel, 8.5 grains of VV N110 is just right for me. I would start at 9 grains and work your way up or down accordingly. I can't help you with other bullet weights.
-Dan
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